Online Courses (English)
This just in:

State PCS

Daily Updates

Science & Technology

Role of Lipids in Infectious Diseases

  • 20 Mar 2020
  • 2 min read

Why in News

Researchers at IIT-Bombay are using biologically active lipid molecules as chemical biology tools to understand their biological disease-causing function.

Lipids

  • Lipids are molecules that contain hydrocarbons and make up the building blocks of the structure and function of living cells.
  • They are responsible for maintaining the integrity of our cell membrane, which allows nutrients and drugs to pass through the cell.
  • They play a major role in altering properties of the cell membrane.
  • During infection and in diseases, the lipids are breached and membranes are harnessed by pathogens for their survival and infection

Key Points

  • The role of lipids in critical mechanisms involved in host-pathogen interplay is being explored.
  • The mechanism of action of Mtb lipids on human host membrane and related cellular events represents a golden opportunity to deepen the understanding of the function of Mtb lipids in membrane-dictated bacterial survival, pathogenesis, and drug resistance.
  • Scientists are also investigating the role of Mtb lipids in drug-membrane interactions, underscored by the fact that lipids critically dictate the molecular interactions of drugs with membranes influencing drug diffusion, partitioning, and accumulation.
  • Membrane structures specific to mycobacterial lipids have also been developed which can act as ‘cell-free’ platforms for anti-tubercular (relating to TB) drug interactions. They would help in:
    • Investigating antibiotic interactions with mycobacterial (causative agent of Tuberculosis) specific membranes for future antibiotic design.
    • Shaping the effectiveness of already existing anti-TB drug molecules and fostering development of new ones.
    • Investigation of host cellular pathways rewired by pathogenic factors and elucidate possible therapeutic targets in Tuberculosis.

Source: PIB

SMS Alerts
 

Please login or register to view note list

close

Please login or register to list article as bookmarked

close
 

Please login or register to make your note

close

Please login or register to list article as progressed

close

Please login or register to list article as bookmarked

close