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Role of Glucose in Regulating Liver Functions

  • 16 Mar 2020
  • 2 min read

Why in News

A study by researchers from the Tata Institute of Fundamental Research, Mumbai (TIFR) has revealed that glucose in the body controls the function of SIRT1 directly.

  • SIRT1 is an enzyme that deacetylates (removal of acetyl) proteins that contribute to cellular regulation (reaction to stressors, longevity).
    • A shortage or absence of the control by glucose may lead to a diabetic-like state, while excess feeding and sustained low levels of SIRT1 can lead to obesity and enhanced ageing.
  • This study paves the way might be beneficial in tackling lifestyle disorders and ageing-related diseases.

Key Points

  • In normal healthy individuals, SIRT1 protein levels are known to increase during fasting and decrease during the feed, which is essential to maintain a balance between glucose and fat metabolism.
  • The glucose controls the functions of a protein SIRT1 which in turn maintains everyday feed-fast cycles and is also associated with longevity.
    • The feed-fast cycle is a basic pattern and the metabolism-related to this is largely taken care of by the liver.
  • Thus, the study shows that both over-activation and under-activation of SIRT1 can lead to diseases.
    • Glucose puts a check on the activity of SIRT1 in the fed state. In the absence of this check, SIRT1 activity increases and results in hyperglycemia in a fasted state, mimicking diabetic state.
    • The constant feeding or high-calorie intake that leads to a sustained reduction in the levels of SIRT1 (by glucose) is associated with ageing and obesity.

Source: TH

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