- 15 Apr 2019
- 3 min read
A team of professors at Anna University, Chennai has developed a device called Antibiogramoscope to deal with antibiotic resistance.
- The research was supported by University Grants Commission (UGC) and Department of Science and Technology (DST).
- The team developed a liquid Antibiotic Sensitivity Testing (AST) medium. To this, a commercially available fluorescent molecule is added along with the sample (body fluid).
- This is transferred to the antibiogramoscope’s microwells which are coated with one type of antibiotic.
- When bacteria grow in the medium, it produces a compound called erucamide, which binds to the fluorescent molecule, turning OFF its fluorescence.
- This means if we see fluorescence in some microwells, those antibiotics are effective in killing the bacteria.
- No fluorescence means the bacteria is growing despite the antibiotic which highlights antibiotic resistance.
- The advantages of Antibiogramoscope over traditional methods are:
- It identifies resistant strains of bacteria much quicker, helping physicians choose the right drug, all at a lower cost.
- The existing method uses a solid medium to grow bacteria, while this new method uses liquid medium giving superior results.
- The system is automated, needing no human intervention once the samples and medium are loaded.
- Antibiogramoscope has cleared validation tests at National Accreditation Board for Testing and Calibration Laboratories (NABL) accredited microbiological lab.
National Accreditation Board for Testing and Calibration Laboratories (NABL)
- NABL is a Constituent Board of Quality Council of India.
- NABL has been established with the objective of providing Government, Industry Associations and Industry in general with a scheme of Conformity Assessment Body’s accreditation which involves third-party assessment of the technical competence of testing including medical and calibration laboratories, proficiency testing providers and reference material producers.
- Quality Council of India (QCI) as a non-profit autonomous society registered under Societies Registration Act, 1860.
- The aim of QCI is to establish an accreditation structure in the country and to spread quality movement in India by undertaking a National Quality Campaign.
- It can be noted that in a separate development which is also significant, the scientists at the Centre for Cellular & Molecular Biology (CCMB) have come up with a way to inhibit the multiplication of bacteria even before the cell wall begins to grow.