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सेमिनार: अंग्रेज़ी सीखने का अवसर (23 सितंबर: दोपहर 3 बजे)
Icelend Creates DNA Map of Entire Nation
Apr 03, 2015

Scientists sequenced the entire genomes of 2,636 people in Iceland have produced a trove of valuable information about the nature, location and frequency of human genetic variations. The new research not only sheds light on the range of human genetic variability; it will help researchers draw more direct lines between genes and diseases. For instance, genetic abnormalities long thought to guarantee early death now appear to be more common than previously believed, the researchers found. They also discovered new genetic contributors to such varied afflictions as Alzheimer's disease, liver disease and atrial fibrillation.

  • By sequencing the full genomes of so many Icelanders and comparing the results with less extensive genotype data from more than 104,000 of their countrymen, the scientists identified more than 20 million genetic variants.

  • They cross-checked those variants against Iceland's extensive genealogical and medical records. That helped them see how specific DNA variants contributed to particular diseases. It also allowed them to see how a single disease passed through generations of a given family.

  • This will also make it easier to identify DNA variants that confer protection from diseases.

  • While Iceland's small and homogeneous population was a factor in making such discoveries possible, the benefits of DeCode's findings are not limited to Icelanders.

Genes responsible for our ability to discriminate between scents were the most commonly knocked-out class. The team found far fewer knockouts in genes that are very active in the brain—suggesting that a gene deletion there would be more harmful.

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