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बेसिक इंग्लिश का दूसरा सत्र (कक्षा प्रारंभ : 22 अक्तूबर, शाम 3:30 से 5:30)
Medical Breakthrough Study: Bangalore Lab Maps Human Protein
May 30, 2014

In what is being called a medical breakthrough study that could change the way in which cancers and heart problems are diagnosed and treated, researchers from the Institute of Bioinformatics (IOB), Bangalore, as part of a 72-member team, have for the first time deciphered a near complete protein map of human beings. While the Johns Hopkins University, Baltimore, is the lead American partner, 46 researchers are Indians. The findings titled A Draft Map of the Human Proteome, could offer deeper insight into why humans suffer from diabetes, cancer and cardiac problems among other diseases.

This is the next big thing that genetic researchers have been waiting for after the human genome project. While researchers had felt that mere sequencing of the genes would unlock the mystery of life, the true potential of the human genome mapping could not be realised. Scientists hit a roadblock as not enough was known about the proteins that translate the genetic information into functional units like enzymes and proteins. Most human diseases and aging happen because proteins and enzymes become dysfunctional—nobody fully understands why.

Although India did not participate in the human genome project, completion of a human proteome map by this team now puts India at the forefront of the international efforts to characterise the human proteome. This should be truly a matter for pride for science and scientists working in India.

While DNA preserves the code of life and the human genome project deciphered that, a similar estimate for proteins, which determine the outcome of life, was not available. The human proteome map is a major step in that direction.The team analysed 30 different tissue samples from adults and foetuses to arrive at the map of proteins coded by 17,294 different genes.

They identified more than 2,000 proteins that were labelled as missing proteins by the international research community as they had never been detected or measured. A remarkable achievement is the identification of almost 200 novel proteins in humans that had not been discovered.


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